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Indications

Adjunctive therapy in partial seizures w/ & w/o secondary generalization in adults & childn ≥6 yr. Monotherapy in partial seizures w/ & w/o secondary generalization in adults & adolescents ≥12 yr. Peripheral neuropathic pain eg, painful diabetic neuropathy & post-herpetic neuralgia in adults.

 

Dosage and Administration

Epilepsy Adult & adolescent Initially, 300 mg tds on day 1. May be further increased in 300 mg daily increments every 2-3 days up to max 3,600 mg daily based on individual patient response & tolerability. Childn ≥6 yr Initially 10-15 mg/kg daily, up-titrated over approx 3 days to reach effective dose of 25-35 mg/kg daily. Total daily dose should be divided in 3 single doses & max time interval between doses should not exceed 12 hr. Peripheral neuropathic pain Adult Initially 900 mg daily given as 3 equally divided doses. May be further increased in 300 mg daily increments every 2-3 days up to max 3,600 mg daily based on individual patient response & tolerability. Renal impairment CrCl ≥80 mL/min 900-3,600 mg daily, 50-79 mL/min 600-1,800 mg daily, 30-49 mL/min 300-900 mg daily, 15-29 mL/min 150-600 mg daily, <15 mL/min 150-300 mg daily. Total daily doses should be administered as 3 divided doses. Patients undergoing haemodialysis Loading dose: 300-400 mg, then 200-300 mg following each 4-hr haemodialysis.